Click R9F2

Ref. 3D-CRB1000119

Produktinformation

• Name: Click R9F2
• Synonyme: 4pentynyl-RRRRRRRRRFF-NH2
• Marke: Biosynth
• Beschreibung: R9F2 is a specifically designed arginine-rich cell penetrating peptide (CPP) for delivery of antisense molecules (AMOs). Synthetic AMOs are used to interfere with translation and RNA synthesis however their delivery into leukocytes has been an issue. The creation of CPPs such as R9F2 has allowed a new more effective method of delivering AMOs for altering gene expression. The design of the arginine rich peptide with two phenylalanine to the C-terminus allowed better interaction with cell membrane and improved uptake of the cargo. R9F2 has been effectively tested on murine leukocytes to evaluate its efficacy at altering pre-mRNA splicing.R9F2 is provided here with a N-terminal alkyne attachment. Two of the most regularly encountered functional groups for click chemistry are azides and alkynes, and the azide-alkyne cycloaddition has become the most popular click reaction. The use of click chemistry with alkyne-R9F2 allows a wide variety of applications particularly for conjugation, modification, and peptide design.

Chemische Eigenschaften

• Molekulargewicht: 1,796.1 g/mol
• Farbe/Form: Powder