TAT (47-57)

CAS: 191936-91-1

Ref. 3D-CRB1000171

Produktinformation

• Name: TAT (47-57)
• Synonyme: H-YGRKKRRQRRR-OH
• Marke: Biosynth
• Beschreibung: Tat (47-57) is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). Specifically TAT (47-57) is located within the arginine-rich basic domain 48-60 of the TAT peptide which as a whole has three domains which function to aid HIV through transactivation, DNA binding and nuclear transport. As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules and hence serves a valuable purpose in transduction methods. This property has been demonstrated through its ability of allowing toxins such as the neurotoxin Botulinum neurotoxin Type A, produced by the Clostridium botulinum type A bacteria to penetrate the skin barrier non-invasively. Additionally TAT (47-57) can be used to deliver proteins, fluorophores, chelators and DNA to target cells.

Chemische Eigenschaften

• Molekulargewicht: 1,559.83 g/mol
• Formel: C₆₄H₁₁₈N₃₂O₁₄
• Farbe/Form: Powder