Biotin-Desmoglein-3 DSG3 (50-79)

Ref. 3D-CRB1000386

Produktinformation

• Name: Biotin-Desmoglein-3 DSG3 (50-79)
• Synonyme: Biot-EWVKFAKPCREGEDNSKRNPIAKITSDYQA-OHBiotin-E-W-V-KFAKPC*REGEDNSKRNPIAKITSDYQA-acidBiotin-Glu-Trp-Val-Lys-Phe-Ala-Lys-Pro-Cys-Arg -Glu-Gly-Glu-Asp-Asn-Ser-Lys-Arg-Asn-Pr o-Ile-Ala-Lys-Ile-Thr-Ser-Asp-Tyr-Gln-Ala-OH

Beschreibung

Desmoglein-3 DSG3 (50-79) is derived from the pemphigus vulgaris antigen DSG3 and is involved in cell-cell adhesion. It can exist as non-junctional and junctional and is one of the desmosomal cadherins. Within the epithelial cells non-junctional DSG3 takes part in E-cadherin signalling.The overexpression of DSG3 has been observed in squamous cell carcinoma and can be used as a biomarker for cervical sentinel lymph nodes. DSG3 in tumours is considered as being pro-metastatic through DSG3 ability to activate AP-1 and the PKC/Ezrin pathway.Biotin (B7) has been added to the N-terminus.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 3,705.9 g/mol
• Farbe/Form: Powder