Phosphorylated LRRKtide

Ref. 3D-CRB1000466

Produktinformation

• Name: Phosphorylated LRRKtide
• Synonyme: H-RLGRDKYK(pT)LRQIRQ-NH2ERM peptideERMtideLeucine-Rich Repeat Kinase substrateMoesinRLGRDKYK-[pT]-LRQIRQ-amideH-Arg-Leu-Gly-Ar g-Asp-Lys-Tyr-Lys-[pThr]-Leu-Arg-Gln-Ile-Arg-Gln-NH2, Where [pThr] is phospho ThreonineE RM peptideERMtideLeucine-Rich

Beschreibung

LRRKtide (also called moesin) is a peptide substrate for leucine-rich repeat kinase 2 (LRRK2). The sequence of LRRKtide has been derived from the ERM proteins: Ezrin (amino acids 561-573), radixin (amino acids 558-570) and moesin (amino acids 539-553). These proteins influence cytoskeletal dynamics by anchoring the cytoskeleton to the plasma membrane. LRRK2 phosphorylates LRRKtide at its Thr558 site. This peptide contains the phosphorylated threonine residue.LRRK2 is a large, ubiquitous protein of unknown function. LRRK2 has GTPase and kinase activity, and is located in multiple areas of the cell, associated with intracellular membranes and vesicular structures- suggesting LRRK2 may be involved in several cellular pathways. LRRK2 is also found in most organs and mutations in LRRK2 have been identified in Parkinson's disease.The threonine residue at position 9 of this peptide has been phosphorylated.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 2,009.1 g/mol
• Reinheit: Min. 95%
• Farbe/Form: Powder