HLA-DRB1*1501 peptide

Ref. 3D-CRB1000570

Produktinformation

• Name: HLA-DRB1*1501 peptide
• Synonyme: H-AVNIVGYSNAQGVDY-OH

Beschreibung

The HLA-DRB1*1501 peptide, is encoded by the disease-associated MHC allele histocompatibility leukocyte antigen (HLA)-DRB1*1501 which is present on the MHC region of chromosome 6. The increased frequency of the HLA-DRB*11501 haplotype found in Multiple Sclerosis (MS) patients, may contribute to the MS phenotype through disrupting T cell repertoire selection and through the presentation of self-peptides which can be targeted by the body's autoimmune response. Moreover studies investigating the accumulation of amyloid β-peptide (Aβ) as a factor producing Alzheimer's disease (AD) pathogenicity, found that HLA-DR alleles such as DRB1*1501 demonstrate immunogenic properties. It is evident that the DRB1*1501 halotype is associated with strong Aβ-T cell responses resulting in the large production of IFN- γ and IL-17. Therefore the HLA-DRB1*1501 peptide would be beneficial in studies exploring the phenotypes of autoimmune-diseases like MS and AD.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,568.7 g/mol
• Reinheit: Min. 95%
• Farbe/Form: Powder