ANP (9-22)

Ref. 3D-CRB1000639

Produktinformation

• Name: ANP (9-22)
• Synonyme: H-GGRMDRIGAQSGLG-OHAtrial natriuretic peptide (ANP)atrial natriuretic factor (ANF)atrial natriuretic hormone (ANH)atriopeptinGG RMDRIGAQSGLG-acidH-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-OH

Beschreibung

ANP (9-22) is derived from the atrial natriuretic peptide (ANP) which is a cardiac hormone involved in maintaining cardio-renal homeostasis. This occurs through the activation of the guanylyl cyclase-coupled receptor, resulting in the increased concentration of cyclic guanylate monophosphate. Moreover its function in the processes of anti-proliferation and anti-angiogenesis allow it to take part in the cardiovascular remodelling process.ANP is a member of the natriuretic peptide family and it is encoded by the NPPA gene, located on chromosome 1. Once synthesized from the 151 amino acid pre-prohormone into its biologically active form, ANP is secreted by the atrial cardiomyocytes in the circulating forms: ANP (1-98) and ANP (99-126). This synthesis process involves the signal peptide being removed from the pre-prohormone resulting in proANP (1-126) which is converted into the circulating forms by the type II transmembrane serine protease Corin.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,373.7 g/mol
• Farbe/Form: Powder