PTP1B Substrate

Ref. 3D-CRB1000746

Produktinformation

• Name: PTP1B Substrate
• Synonyme: DADE-[pTyr]-LIPQQG-acidH-Asp-Ala-Asp-Glu-[pTyr]-Leu-Ile-Pro-Gln-Gln-Gly-OHEGF Receptor Substrate 2

Beschreibung

Substrate peptide for protein tyrosine phosphatase 1B (PTP1B)- an ubiquitously expressed non-receptor tyrosine phosphatase. PTP1B negatively regulates signalling pathways controlling metabolic homeostasis, cell proliferation and immunity (such as leptin and insulin receptor signalling), making PTP1B an interesting target for type 2 diabetes mellitus (T2DM) and obesity treatment. PTP1B also has important leptin-independent metabolic effects, playing a critical role in the regulation of inflammation, cell proliferation, differentiation and invasion. Therefore PTP1B is also interesting as a therapeutic target for inflammatory and autoimmune diseases and cancer.-For application data please see: Figure 2 supplement 1C.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,327.5 g/mol
• Reinheit: Min. 95%