Histone H1 derived peptide

Ref. 3D-CRB1000934

Produktinformation

• Name: Histone H1 derived peptide
• Synonyme: H-GGGPATPKKAKKL-OHGGGPATPKKAKKL-acidH-Gly-Gly-Gly-Pro-Ala-Thr-Pro-Lys-Lys-Ala-Lys-Lys-Leu-OHcyclin dependent protein kinase 7 sub strate, cyclin
• Marke: Biosynth
• Beschreibung: H1 is the linker histone and is important for chromatin condensation, it binds to the nucleosomal core particles and protects the free linker DNA (ˆ¼20 bp) between each nucleosome. H1 can fine-tune transcription in a locus-specific manner. H1 is involved in several processes, its interaction partners include: pre-mRNA splicing factors- histone chaperones- components of the transcription machinery and DNA-damage response factors. There a 12 subtypes of the H1 linker histone, and they are thought to have specific functions, making H1 the most divergent histone protein family. Like other histones, H1's are extensively post-translationally modified with modifications including: methylation, acetylation, ubiquitination, formylation, poly-ADP ribosylation and phosphorylation.Changes in H1 composition and expression levels are seen in several cancers and other diseases.

Chemische Eigenschaften

• Molekulargewicht: 1,251.8 g/mol
• Farbe/Form: Powder