Produktinformation
Name:Angiopep 2
Synonyme:
- H-TFFYGGSRGKRNNFKTEEY-OH
Marke:Biosynth
Beschreibung:Part of the angiopep family of peptides which have been derived from the Kunitz domain of human aprotinin. These peptides are able to cross the blood brain barrier (BBB) and have been used to facilitate the delivery of pharmacological agents to the brain, for example to target glioblastoma tumours and recurrent brain metastases of pre-treated breast cancers. Angiopep-2 has higher transcytosis capacity and higher brain volume of distribution than aprotinin. Like aprotinin, angiopep-2 interacts with low-density lipoprotein receptor-related protein 1 (LRP1) which is thought to promote its delivery across the BBB via receptor-mediated transcytosis (RMT). However the interaction with LRP1 may not be the only method for angiopep-2 to cross into the brain.
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Chemische Eigenschaften
Molekulargewicht:2,301.51 g/mol
Farbe/Form:Powder