N-formylated PSMalpha2

Ref. 3D-CRB1001357

Produktinformation

• Name: N-formylated PSMalpha2
• Synonyme: For-MGIIAGIIKFIKGLIEKFTGK-OHFormyl-MGIIAGIIKFIKGLIEKFTGK-acidFormyl-Met-Gly-Ile-Ile-Ala-Gly-Ile-Ile-Lys-Phe-Ile-Lys-Gly-Leu-Ile-Gl u-Lys-Phe-Thr-Gly-Lys-OH
• Marke: Biosynth
• Beschreibung: Pathogenic Staphylococcus aureus strains produce N-formylmethionyl containing peptides. Peptides starting with an N-formylated methionyl group constitute a unique hallmark of bacterial as well as mitochondrial metabolism, and professional phagocytes of our innate immune system recognise this microbial/mitochondrial pattern as a danger signal that guides innate immune cells.All PSMα peptides have the same basic functions and promote virulence through effects on discrete neutrophil functions (i.e. chemotaxis) and by being cytotoxic at higher concentrations. PSMα2 and PSMα3 can both bind to FPR2 and trigger superoxide release in neutrophils at low nanomolar concentrations. In addition, at high nanomolar concentrations they display cytotoxicity selectively on apoptotic neutrophil membranes and this occurs in an FPR2 independent manner.

Chemische Eigenschaften

• Molekulargewicht: 2,304.4 g/mol
• Farbe/Form: Powder