Pep2-8

Ref. 3D-CRB1001429

Produktinformation

• Name: Pep2-8
• Synonyme: Ac-TVFTSWEEYLDWV-NH2

Beschreibung

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is negative regulator of hepatic low-density lipoprotein (LDL) receptors by promoting their degradation. This leads to an increase in plasma levels of cholesterol-LDL (LDL-c). PCSK9 binds to the LDL receptor at the epidermal growth factor precursor homology domain A (EGF-A) which leads the receptor to be targeted for degradation. Natural loss of function mutations in PCSK9 have been linked to improved coronary health and lower cholesterol levels with reduced risk of coronary heart disease. This has led to further study to find inhibitors of PCSK9 with the hope that they may be clinically relevant in the future.As discussed, PCSK9 binds to EGF-A on the LDL receptor. A peptide named pep 2-8 is a mimic of EGF-A and binds PCSK9 in the same manner observed with the LDL receptor. Pep 2-8 is a potent selective competitive inhibitor of PCSK9. Pep 2-8 restores LDL receptor function and LDL uptake of PCSK9-treated HepG2 cells. This is still an active area of research to optimise inhibition of PCSK9 for cholesterol regulation.Pep 2-8 has also been utilised as an anchor peptide in phage-display experiments to bind an extension peptide library to the groove site.Peptide Ac-TVFTSWEEYLDWV-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using Ac-TVFTSWEEYLDWV-NH2 include the following: LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153-421): design, synthesis and biochemical evaluation RH Alghamdi, P O'Reilly, C Lu, J Gomes - European journal of , 2015 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0223523415000422 Biological characterization of computationally designed analogs of peptide TVFTSWEEYLDWV (Pep2-8) with increased PCSK9 antagonistic activity C Lammi, J Sgrignani , A Arnoldi , G Grazioso - Scientific reports, 2019 - nature.comhttps://www.nature.com/articles/s41598-018-35819-0 Computational design and biological evaluation of analogs of lupin peptide p5 endowed with dual pcsk9/hmg-coar inhibiting activity C Lammi, EMA Fassi, J Li , M Bartolomei, G Benigno - Pharmaceutics, 2022 - mdpi.comhttps://www.mdpi.com/1999-4923/14/3/665 Molecular dynamics insights on the role beta-augmentation of the peptide N-terminus with binding site beta-hairpin of proprotein convertase subtilisin/kexin 9 B Pasam, KM Medicherla , RS Rathore - Chemical Biology & , 2019 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13612

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,714.8 g/mol
• Reinheit: Min. 95%