Rituximab Light chain (41-55)

Ref. 3D-CRB1001520

Produktinformation

• Name: Rituximab Light chain (41-55)
• Synonyme: H-SSPKPWIYATSNLAS-OH
• Marke: Biosynth
• Beschreibung: Rituximab is a chimeric monoclonal antibody used in the treatment of some cancers like CD20 non-Hodgkin's lymphoma and a few autoimmune conditions such as rheumatoid arthritis. However, antibody treatment can lead to generation of neutralising antibodies thus curtailing the efficacy of the therapy. CD 4+ T cells are critical to initiate antibody response so identification of epitopes within molecules using T cell assays can be a vital tool for understanding the immune response and thereby prevent induction of neutralising antibodies. Within rituximab, the variable region of the light chain (41-55) was found to have strong affinity for leukocytes in a specific binding assay, the epitope was also correlated to patients who developed neutralising antibodies. This T cell epitope within rituximab in further immune studies could help design or selection of antibodies without T cell epitopes present for low immunogenicity.

Chemische Eigenschaften

• Molekulargewicht: 1,620.8 g/mol