MART-1 (26-35)

CAS: 156251-01-3

Ref. 3D-CRB1001607

Produktinformation

• Name: MART-1 (26-35)
• Synonyme: H-EAAGIGILTV-OHMelan-A, Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val, Eaagigiltv, Antigen Sk29-Aa (26-35) (Human), Antigen Lb39-Aa (26-35) (Human), Mart 1 (26-35), Mart-1 (26-35) (Human), Melanoma Antigen Recognized By T-Cells 1 (26-35) (Human)

Beschreibung

Melan-A residues/ Melanoma Antigen Recognised by T-cells (MART)-1 residues 26-35 is a tumour associated antigen expressed in the majority of melanoma cells.This peptide is an immunodominant epitope recognised by CD8+ tumour-infiltrating T- lymphocytes (TIL) and stems from the degradation of Melan-A antigen. The peptide is loaded onto the major histocompatibility class-I (MHC-I) HLA-A2 molecule in the endoplasmic reticulum, and transported to the cell surface where is it presented to T-cell receptors (TCRs) for inspection.HLA-A*0201 is a class I major histocompatibility complex (MHC) allele which is part of the HLA-A group of human major histocompatibility complex (MHC) leukocyte antigens (HLA). HLA-A is a human MHC class I cell surface receptor and is involved in presenting short polypeptides to the immune system. These polypeptides are typically 7-11 amino acids in length and originate from proteins being expressed by the cell. Cytotoxic T cells in the blood (CD8+ T-cells) "read" the peptide presented by the complex and should only bind to non-self peptides. If binding occurs, a series of events is initiated culminating in cell death via apoptosis.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 943.1 g/mol
• Formel: C₄₂H₇₄N₁₀O₁₄
• Farbe/Form: Powder