Pepstatin A
Ref. 3D-CRB1001649
| 1mg | 150,00 € | ||
| 500µg | 110,00 € |
Produktinformation
- isovaleryl-Val-Val-Sta-Ala-Sta-OH
Pepstatin A was originally purified from Actinomycetes species. The peptide is unusual in containing the amino acid statine (4-amino-hydroxy-6-methylheptanoic acid also known as AMHA). Pepstatin A competitively binds with acid proteases in a highly selective reversible manner to inhibit protease activity. Pepstatin A is ineffective on thiol, neutral and serine proteases. The functions of proteases have been investigated by the application of pepstatin A such as renin, pepsin, bovine chymosin and retroviral proteases from HIV. Characterisation of HIV protease using pepstatin A has been vital in development of HIV treatment to block viral replication. Pepstatin A is also a reagent to disrupt autophagy- this helps characterise the function of proteosome degradation in research such as during influenza A replication and improving drug delivery of therapeutic cancer treatments.
Chemische Eigenschaften
Technische Anfrage zu: 3D-CRB1001649 Pepstatin A
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