Annexin A5 (30-45) Heavy

Ref. 3D-CRB1300797

Produktinformation

• Name: Annexin A5 (30-45) Heavy
• Synonyme: GLGTDEESILTLLTS-[U-13C6,15N4-Arg]-acidH-Gly-Leu-Gly-Thr-Asp-Glu-Glu-Ser-Ile-Leu-Thr-Leu-Leu-Thr-Ser-[U-13C6,15N4-Arg]-OH

Beschreibung

Annexin A5 (30-45) Heavy, derived from the annexin A5 protein is a member of the annexin family which is dependent on Ca2+ to bind reversibly to negatively charged phospholipids located on cell membranes. It has been shown that annexin A5 forms a two dimensional crystalline array when it binds to the membrane, allowing it to immobilise membrane proteins. This property allows annexin A5 to exhibit rupture-resealing activity. When the membrane becomes ruptured there is a large influx of Ca2+ ions into the cells, consequently annexin A5 binds to the ruptured area and the resealing of the area occurs due to the formation of annexin A5 two dimensional crystalline arrays.Annexin A5 can be used to image apoptosis through binding to the apoptotic marker Phosphatidylserine.The Arginine residue at position 9 has been isotopically labelled with carbon-13 (6) and nitrogen-15 (4), giving this peptide a mass increase of 16 compared to the unlabelled peptide.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,713.9 g/mol
• Reinheit: Min. 95%