Ubiquitin K6 Heavy

Ref. 3D-CRB1300806

Produktinformation

• Name: Ubiquitin K6 Heavy
• Synonyme: H-MQIFV(K/H-GG)TLTGK^-OHMQIFV-[K(GG)]-TLTG-[13C6,15N2-Lys]-acidH-Met-Gln-Ile-Phe-Val-[Lys-(Gly-Gly)]-Thr-Leu-Thr-Gly-[U-13C6,15N2- Lys]-OH
• Marke: Biosynth
• Beschreibung: This sequence corresponds to the peptide bond between mammalian Lys6- (K6) linked Ub proteins- where (GG) corresponds to the C-terminus of the side chain appended Ub.K6-linked Ub chains have been liked to DNA damage response and to the E3 Ub ligase BRCA1. K6 chains have also been shown to be important for mitophagy. The RING-in-between-RING (RBR) E3 ligases RNF144A and RNF144B assemble K6-linked chains in vitro. The homologous to the E6AP carboxyl terminus (HECT) E3 ligase HUWE1 also assembles K6-linked chains in vitro.The C-terminal lysine residue of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (2), giving this peptide a mass increase of 8 compared to the unlabelled peptide.

Chemische Eigenschaften

• Molekulargewicht: 1,386.8 g/mol
• Reinheit: Min. 95%
• Farbe/Form: Powder