α-1-acid glycoprotein 1 Heavy

Ref. 3D-CRB1301088

Produktinformation

• Name: α-1-acid glycoprotein 1 Heavy
• Synonyme: H-YVGGQEHFAHLLIL^R-OHYVGGQEHFAHLLI-[U-13C6,15N-Leu]-R-acidH-Tyr-Val-Gly-Gly-Gln-Glu-His-Phe-Ala-His-Leu-Leu-Ile-[U-13C6,15N-Leu]-A rg-OH
• Marke: Biosynth
• Beschreibung: Alpha-1-acid glycoprotein (AAG) is one of the major proteins involved in sequestering drugs in the plasma such as: lidocaine- propranolol- verapamil- steroid hormones and phenobarbital. AAG is a member of the acute phase protein (APP) family and is formed primarily in the liver and circulates at low levels in the plasma of healthy humans. In many diseased states including inflammation, infection, and cancer, AAG levels increase from 2 to 6-fold in humans. AAG can regulate immunity and plays a role in both pro- and anti-inflammatory response.AGG forms a positive feedback loop to exert anti-fatigue functions via the CCR5 receptor and therefore AGG, and CCR5 could be novel targets for the therapeutic intervention of fatigue.The leucine residue at position 14 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.

Chemische Eigenschaften

• Molekulargewicht: 1,759 g/mol
• Reinheit: Min. 95%