Oxytocin (free acid) Heavy

Ref. 3D-CRB1301293

Produktinformation

• Name: Oxytocin (free acid) Heavy
• Synonyme: [Cyc(1,6)]H-CYIQNCP^L^G-OHCYIQNC-[U-13C5,15N-Pro]-[U-13C6,15N-Leu]-G-acid (Disulphide bridge Cys1 - Cys6)H-Cys-Tyr-Ile-Gln-Asn-Cys -[U-13C5,15N-Pro]-[U-13C6,1 5N-Leu]-Gly-OH (Disulphide bridge Cys1 - Cys6)
• Marke: Biosynth
• Beschreibung: Neuropeptide and hormone involved in many processes, including- social bonding--sexual reproduction- childbirth and breastfeeding. Oxytocin is synthesised in the hypothalamus as a prepropeptide consisting of a signal peptide, the oxytocin peptide hormone, a processing signal and the carrier protein- neurophysin. The prohormone then undergoes endoproteolytic cleavage and amidation to form the final oxytocin peptide. Dysregulation of oxytocin has been implicated in the pathophysiology of neuropsychiatric disorders that impact social functioning, such as autism, schizophrenia, and depression as well as anorexia nervosa. Intranasal oxytocin administration may reduce amygdala activity and amygdala-midbrain connectivity in response to fearful situations- reduce cortisol release and anxiety in response to psychosocial stress- increase trust behaviour- increase the ability to interpret mental states, and increase the amount of time spent gazing at the eyes when viewing faces.The proline residue at position 7 and the leucine residue at position 8 of this peptide are isotopically labelled with carbon-13 (11) and nitrogen-15 (2), giving this peptide a mass increase of 13 compared to the unlabelled peptide.

Chemische Eigenschaften

• Molekulargewicht: 1,020.5 g/mol
• Reinheit: Min. 95%