Anti-GLAST antibody - 1mg/mL

Ref. 3D-CRB2005009

Produktinformation

• Name: Anti-GLAST antibody - 1mg/mL

Beschreibung

GLAST/ EAAT-1 (Glutamate-Aspartate Transporter/ Excitatory Amino Acid transporter 1) (rodent/human nomenclature) is a sodium-dependent plasma membrane glutamate transporter expressed exclusively by astrocytes in the cerebellum and present at high densities near excitatory synapses. Glutamate transporters regulate glutamate receptors and limit glutamate accumulation to prevent neurotoxicity whilst ensuring accurate synaptic communication. GLAST is the major transporter expressed during development.

Loss of GLAST/EAAT-1 has been linked to the pathogenesis of several disorders affecting the motor system including several subtypes of spinocerebellar ataxia (SCA); SCA1, SCA5, SCA7, episodic ataxia type 6, spinal muscular atrophy and fragile X associated tremor/ataxia syndrome. Furthermore, disrupted GLAST/EAAT-1 has been associated with schizophrenia and cerebellar dysfunction and also is linked to the pathophysiology of Alzheimer's disease, autism and other cognitive and neuropsychiatric disorders.

Data: Western blot analysis of rat brain preparation.
Lane 1: Rat brain preparation (10µg).
Secondary: Goat anti-rabbit IgG conjugated to HRP 1:2000.

• Marke: Biosynth

Chemische Eigenschaften

• Farbe/Form: Powder