Anti-p21 antibody - 1mg/mL

Ref. 3D-CRB2005030

Produktinformation

• Name: Anti-p21 antibody - 1mg/mL

Beschreibung

The multi-functional cyclin-dependent kinase (CDK) inhibitor p21, also known as p21WAF1/Cip1 or CDKN1A functions as a cell cycle inhibitor and anti-proliferative effector. Upon DNA damage and genotoxic stress, the tumour suppressor p53 is activated and induces the expression of p21. p21 has also been implicated in nucleotide excision repair (NER), base excision repair (BER) and DNA translesion synthesis (TLS) by disrupting the proliferating cell nuclear antigen (PCNA) interaction with other DNA repair factors and promoting PCNA degradation.

Data: University of Liverpool Western blot analysis of whole cell extract of human osteocarcinoma (U-2 OS) (20µg).
Lane 1: U-2 OS cells
Lane 2: U-2 OS cells transfected with siRNA p21 (48h)

• Marke: Biosynth

Chemische Eigenschaften

• Farbe/Form: Powder