Anti-Phospho-GluR1 (pS845) antibody - 1mg/mL

Ref. 3D-CRB2005048

Produktinformation

• Name: Anti-Phospho-GluR1 (pS845) antibody - 1mg/mL

Beschreibung

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is an ionotropic transmembrane receptor for glutamate found throughout the central nervous system (CNS). AMPARs are composed of four types of subunits: GluR1/GluA1, GluR2/GluA2, GluR3/GluA3, and GluA4 (GluRA-D2), which combine to form heterotetramers.

Phosphorylation of AMPARs is often implicated in synaptic plasticity and the pathological signalling seen in several disease states. Phosphorylation of GluR1 at serine 845 has been implicated in specific neurological diseases including paediatric seizures. Phosphorylation of the S845 of the GluR1 subunit is controlled by cGKII, a kinase activated by an increase in nitric oxide (NO) levels within the cytosol, and PKA, activated by the calcium dependent production of cAMP. GluR1 S845 is dephosphorylated by the protein phosphatases PP1, PP2A, and CaN (also known as PP2B).

• Marke: Biosynth