Anti-KA1 antibody - 0.4mg/mL

Ref. 3D-CRB2005050

Produktinformation

• Name: Anti-KA1 antibody - 0.4mg/mL

Beschreibung

Glutamate is the principal excitatory neurotransmitter in the central nervous system (CNS), and imbalances in glutamatergic transmission have profound behavioural and physiological consequences. KA1 is a kainate receptor, which are atypical members of the glutamate receptor family able to signal through both ionotropic and metabotropic pathways. KA1 plays a role in memory and behaviour, and aberrant KA1 expression is seen in neurodegeneration, schizophrenia and bipolar disorder.

The KA1 subunit shows very limited and well-defined expression in just a few neuronal cell types after birth. In the hippocampus KA1 mRNA is expressed at high levels in the CA3 pyramidal neurons and at very low levels in granule cells in the dentate gyrus. In all other neurons in the hippocampus, KA1 is absent.

Data: Western blot analysis of rat brain preparation.
Lane 1: Rat brain preparation (10µg).
Secondary: Goat anti-rabbit IgG conjugated to HRP 1:2000.

• Marke: Biosynth