Anti-GluR1 antibody - 1mg/mL

Ref. 3D-CRB2005075

Produktinformation

• Name: Anti-GluR1 antibody - 1mg/mL

Beschreibung

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is an ionotropic transmembrane receptor for glutamate found throughout the central nervous system (CNS). AMPARs are composed of four types of subunits: GluR1/GluA1, GluR2/GluA2, GluR3/GluA3, and GluA4 (GluRA-D2), which combine to form heterotetramers. The function of AMPARs is determined by the composition of AMPAR subunits and GluR1 is found in the dorsal horn region of the spinal cord. GluR1-containing AMPARs are permeable to Ca2+ and the presence of GluR1-containing AMPARs in synapses contributes to the formation of long-term potential. GluR1 is involved in synaptic plasticity and the expression of the GluR1 gene is reduced with age.

Data: Immunohistochemistry analysis of Paraformaldehyde-fixed mouse brain section.
Strong immunoreactivity in the cerebellar molecular layer (cbm) and hippocampal formation (HF) characteristic of GluR1 distribution.

• Marke: Biosynth