Anti-GluR2 antibody - 1mg/mL

Ref. 3D-CRB2005076

Produktinformation

• Name: Anti-GluR2 antibody - 1mg/mL

Beschreibung

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is an ionotropic transmembrane receptor for glutamate found throughout the central nervous system (CNS). AMPARs are composed of four types of subunits: GluR1/GluA1, GluR2/GluA2, GluR3/GluA3, and GluA4 (GluRA-D2), which combine to form heterotetramers.

The function of AMPARs is determined by the composition of AMPAR subunits. GluR2-containing AMPARs have little Ca2+ permeability. The GluR2 subunit interacts with several proteins and regulates the lysosomal targeting and degradation of AMPARs.

Defects in expression of GluR2 may be involved to the development of motor neurone disease (MDN/ALS).

• Marke: Biosynth