Anti-FGFR2c antibody - 1mg/mL

Ref. 3D-CRB2005090

Produktinformation

• Name: Anti-FGFR2c antibody - 1mg/mL

Beschreibung

The fibroblast growth factor receptor (FGFR) family consists of four transmembrane receptor tyrosine kinases (FGFR1-4), which regulate important physiological processes, such as cell proliferation, differentiation, migration and survival throughout the body. FGFR2c is known as the mesenchymal FGFR2 isoform and when aberrantly expressed in epithelial cells it induces epithelial-mesenchymal transition (EMT) and is involved in cancer progression. FGFR2 signalling is critical for proper craniofacial development. A gain-of-function mutation in the 2c splice variant is associated with Crouzon syndrome, which is characterized by craniosynostosis, the premature fusion of one or more of the cranial vault sutures, leading to craniofacial maldevelopment. FGFR2c-mediated ERK-MAPK signalling is a key mediator of craniofacial growth and coronal suture development.
1mg/ml. For use in WB (1:1000) and ELISA (1:1000). Reacts with human.
Image: Western blot analysis of conditioned media from non-transfected HEK293 cells.

• Marke: Biosynth