Anti-SLC15A4 antibody - 0.2mg/mL

Ref. 3D-CRB2005113

Produktinformation

• Name: Anti-SLC15A4 antibody - 0.2mg/mL

Beschreibung

Solute carrier family member 15A4 (SLC15A4) is a lysosome-resident, proton-coupled histidine/oligopeptide transporter that has 12 membrane-spanning regions. SLC15A4 is expressed in haematopoietic lineage cells, including dendritic cells and B-cells, where it transports certain amino acids and oligopeptides to the cytosol, along with a proton from the inside of the late endosome/lysosome. SLC15A4 is critical for the production of type I interferon (IFN-I). SLC15A4's transporter activity is required to optimize pH and other conditions required for signalling in the late endosomes/lysosomes as well as in specialised lysosomes know as secretory granules present in mast cells. SLC15A4-mediated regulation of signalling in these compartments is an integral part of innate immune responses and may play a role in autoimmune diseases.

• Marke: Biosynth