Anti-p12 antibody - serum

Ref. 3D-CRB2005300

Produktinformation

• Name: Anti-p12 antibody - serum

Beschreibung

P12 is a cleavage product from the murine leukaemia virus (MLV) Gag protein and is essential for various steps in viral replication and during both early and late stages of murine leukaemia virus (MLV) infection.

The N- and C-terminal regions of p12 are sequentially acting domains, both required for p12 function. The N-terminal domain of p12 binds directly to the MLV capsid protein (CA), thus stabilising the capsid shell and viral core. p12 contains the PPPY late-domain (L-domain), which is essential for recruiting HECT ubiquitin ligases which regulate pathways to ensure efficient budding.

Data: p12 and CA co-localise on mitotic chromatin.HeLa cells synchronised using a double-aphidicolin block were infected with WT Mo-MLV VLPs or mutants carrying p12_mut14 or IN_W390A. 10 h post-infection.

• Marke: Biosynth