AF488 Anti-GLAST antibody - 0.56mg/mL

Ref. 3D-CRB2115009

Produktinformation

• Name: AF488 Anti-GLAST antibody - 0.56mg/mL
• Synonyme: Alexa Fluor ® 488 Anti-GLAST antibody

Beschreibung

GLAST/ EAAT-1 (glutamate-aspartate transporter/ excitatory amino acid transporter 1) (rodent/human nomenclature) is a sodium-dependent plasma membrane glutamate transporter expressed exclusively by astrocytes in the cerebellum and present at high densities near excitatory synapses. The cerebellum is the region of the brain essential for maintaining postural control and coordination of voluntary muscle movement. Glutamate transporters regulate glutamate receptors and limit glutamate accumulation to prevent neurotoxicity whilst ensuring accurate synaptic communication. GLAST is the major transporter expressed during development. Loss of GLAST/EAAT-1 has been linked to the pathogenesis of several disorders affecting the motor system including several subtypes of spinocerebellar ataxia (SCA); SCA1, SCA5, SCA7, episodic ataxia type 6, spinal muscular atrophy and fragile X associated tremor/ataxia syndrome. Furthermore, disrupted GLAST/EAAT-1 has been associated with schizophrenia and cerebellar dysfunction and also is linked to the pathophysiology of Alzheimer's disease, autism and other cognitive and neuropsychiatric disorders. This antibody has AF488 conjugated to it. AF488 is a popular bright green fluorescent dye with high PH-stability.

• Marke: Biosynth