MDK74978

CAS: 778274-97-8

Ref. 3D-DGB27497

Produktinformation

• Name: MDK74978

Beschreibung

MDK74978 is a small molecule that binds to the ATP-binding site of the HIF-1α kinase and inhibits its activity. It has been shown to inhibit the activity of other multi-kinase enzymes, such as PKCθ, Akt, and ERK1/2. MDK74978 has shown efficacy in animal models for treatment of iron overload disorders, such as hereditary hemochromatosis (HFE) and thalassemia major (HBA). In these models, MDK74978 improved iron homeostasis by increasing hepcidin synthesis in hepatocytes. This drug also showed efficacy in a mouse model with chronic kidney disease (CKD), which may be due to its ability to regulate erythropoietin production and enhance erythropoiesis.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 418.38 g/mol
• Formel: C₂₀H₁₇F₃N₄O₃
• Reinheit: Min. 95%