4-Methylumbelliferyl 2-acetamido-2-deoxy-b-D-galactopyranoside-6-sulfate potassium salt

CAS: 383160-14-3

Ref. 3D-EM03197

Produktinformation

• Name: 4-Methylumbelliferyl 2-acetamido-2-deoxy-b-D-galactopyranoside-6-sulfate potassium salt
• Marke: Biosynth
• Beschreibung: 4-Methylumbelliferyl 2-acetamido-2-deoxy-beta-D-galactopyranoside-6-sulfate potassium salt is a fluorogenic substrate for N-acetylgalactosamine-6-sulfatase. After enzymatic cleaveage, free 4-methylumbelliferone (also known as hymecromone) is released, exhibiting blue fluorescence upon excitation with UV light. The strongest fluorescence of 4-methylumbelliferone requires deprotonation of the hydroxyl group (thus requires alkaline pH), with a maximal fluorescence intensity obtained with excitation at 350 to 370 nm and emission at 440 to 470 nm. The use of 4-methylumbelliferyl 2-acetamido-2-deoxy-beta-D-galactopyranoside-6-sulfate potassium saltas a substrate for measuring the N-acetylgalactosamine-6-sulfatase activity is used for diagnosis of Mucopolysaccharidosis IVA (MPS IVA) (a rare lysosomal storage disorder) and Morquio A syndrome screening.

Chemische Eigenschaften

• Molekulargewicht: 497.52 g/mol
• Formel: C₁₈H₂₀KNO₁₁S
• Reinheit: Min. 95%
• Farbe/Form: Powder