4-Methylumbelliferyl 2-acetamido-2-deoxy-a-D-glucopyranoside

CAS: 80265-04-9

Ref. 3D-EM182013

Produktinformation

• Name: 4-Methylumbelliferyl 2-acetamido-2-deoxy-a-D-glucopyranoside
• Synonyme: 4-Methylumbelliferyl N-acetyl-a-D-glucosaminide4MU-a-GlcNAc
• Marke: Biosynth
• Beschreibung: 4-Methylumbelliferyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside is a fluorogenic substrate for alpha-N-acetylglucosaminidase. After enzymatic cleaveage, free 4-methylumbelliferone (also known as hymecromone) is released, exhibiting blue fluorescence upon excitation with UV light. The strongest fluorescence of 4-methylumbelliferone requires deprotonation of the hydroxyl group (thus requires alkaline pH), with a maximal fluorescence intensity obtained with excitation at 350 to 370 nm and emission at 440 to 470 nm. The use of 4-methylumbelliferyl 2-acetamido-2-deoxy-alpha-D-glucopyranosideas a substrate for measuring the alpha-N-acetylglucosaminidase activity is used for Sanfilippo syndrome B screening and mucopolysaccharidosis diagnosis.

Chemische Eigenschaften

• Molekulargewicht: 379.36 g/mol
• Formel: C₁₈H₂₁NO₈
• Reinheit: Min. 98 Area-%
• Farbe/Form: Powder