AZ PFKFB3 26

CAS: 1704740-52-2

Ref. 3D-ETC74052

Produktinformation

• Name: AZ PFKFB3 26
• Synonyme: (S)-N-(4-((3-Cyano-1-isobutyl-1H-indol-5-yl)oxy)phenyl)pyrrolidine-2-carboxamide
• CAS: 1704740-52-2

Beschreibung

AZ PFKFB3 26 is a mutant form of the protein PFKFB3, which is involved in the regulation of glycolysis and cell growth. This mutation causes the protein to become insensitive to inhibition by the drug AZD6244. The mutant form of PFKFB3 also has an aberrant metabolic phenotype that sensitizes cells to glucose deprivation and activates cell growth pathways such as glycolysis. These effects are caused by activating AMPK and mTORC1, two proteins that regulate cell metabolism.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 402.49 g/mol
• Formel: C₂₄H₂₆N₄O₂
• Reinheit: Min. 95%