AF-2

CAS: 146269-94-5

Ref. 3D-FA108494

Produktinformation

• Name: AF-2
• Synonyme: H-Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2 H-KHEYLRF-NH2, Fmrfamidelike peptide AF2, Lys-his-glu-tyr-leu-arg-phe-NH2, L-Phenylalaninamide, L-lysyl-L-histidyl-L-alpha-glutamyl-L-tyrosyl-L-leucyl-L-arginyl-, L-lysyl-3-(4H-imidazol-4-yl)-L-alanyl-L-alpha-glutamyl-L-tyrosyl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithyl-L-phenylalaninamide

Beschreibung

AF-2 is a potent, selective and competitive antagonist at the nicotinic acetylcholine receptor (nAChR). AF-2 binds to the extracellular domains of the nAChR and prevents agonists from binding. It has been shown to inhibit acetylcholine release in isolated heart preparations with high affinity and selectivity. The drug has been tested as an anthelmintic against Caenorhabditis elegans and found to be effective. AF-2 is a cholinergic compound that binds to ganglia, leading to a biphasic response. It also has significant effects on the central nervous system, inhibiting both nicotinic and muscarinic acetylcholine receptors.
AF-2 is sequenced according to the following formula:
H-Lys-His-Glu-Tyr-Leu-Arg-Phe
NH2

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 991.15 g/mol
• Formel: C₄₇H₇₀N₁₄O₁₀
• Reinheit: Min. 95%