Alteplase

CAS: 105857-23-6

Ref. 3D-FA170898

Produktinformation

• Name: Alteplase
• Synonyme: Alteplase [USAN:INN:BAN:JAN], A serine protease with a primary sequence composed of 527 amino acids. The sequence is identical to the naturally occurring protease produced by endothelial cells of vessel walls. Plasminogen activator (human tissue-type protein moiety), Actilyse, Activase, Alteplasi, Alteplasum, Alteplasum [INN-Latin], Cathflo Activase, Grtpa, Recombinant human tissue-type plasminogen activator, Srt-Pa, Tissue plasminogen activator (recombinant human), Unii-1Rxs4Ue564, Plasminogen activator (human tissue-type 2-chain form protein moiety)

Beschreibung

Alteplase is a recombinant tissue-type plasminogen activator (tPA) that is used for the treatment of acute myocardial infarction. Alteplase belongs to the group of thrombolytic agents and has shown to be effective in restoring blood flow to the heart by breaking down clots. It also increases patency rates on patients who have undergone thrombectomy. The enzyme inhibitors can be classified into two groups: those that inhibit tPA, such as heparin and hirudin, and those that inhibit other enzymes, such as streptokinase. Alteplase is used for the treatment of acute myocardial infarction because it reduces mortality rates when administered within three hours after onset of symptoms. This drug also has been shown to reduce creatine kinase levels in patients with congestive heart failure, but does not improve symptoms.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 7,050.95 g/mol
• Formel: C₃₀₀H₄₆₅N₉₅O₈₉S₇