Apicidin

CAS: 183506-66-3

Ref. 3D-FA17952

Produktinformation

• Name: Apicidin
• Synonyme: Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]Cyclo(8-oxo-L-2-aminodecanoyl-1-metho xy-L-tryptophyl-L-isoleucyl-D-2-piperidinecarbonyl)Apicidin ia, Cyclo-L-(2-Amino-8-Oxodeacanoyl)-L-(N-Methoxy-Tryptophan)-L-Isoleucyl-D-Pipecolinyl, Cyclo-[L-(2-Amino-8-Oxodecanoyl)-L-(N-Methoxytryptophan)-L-Isoleucyl-D-Pipecolinyl, Cyclo[(2S)-2-Amino-8-Oxodecanoyl-1-Methoxy-L-Tryptophyl-L-Isoleucyl-(2R)-2-Piperidinexcarbonyl], Apicidin, Fusarium Species, (3S,6S,9S,15aR)-6-[(1-methoxy-1H-indol-3-yl)methyl]-9-[(1S)-1-methylpropyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone

Beschreibung

Apicidin is a cyclic peptide that is structurally similar to the natural antibiotic apigenin. It has been shown to inhibit cancer cell proliferation and induce apoptosis in vitro. Apicidin has also been shown to be effective against squamous carcinoma, hl-60 cells, and mitochondrial membrane potential, as well as other types of cancer cells in vivo. Apicidin binds to the mitochondrial membrane and inhibits ATP synthesis by blocking the electron transport chain. This causes a decrease in cellular energy production and an increase in intracellular oxidative stress which leads to apoptosis.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 623.78 g/mol
• Formel: C₃₄H₄₉N₅O₆
• Reinheit: Min. 95%