Produktinformation
Name:Azatadine dimaleate
Synonyme:
- 6,11-Dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridineAzatadine Dimaleate
Marke:Biosynth
Beschreibung:Azatadine is an antihistamine that has been shown to be clinically relevant for the treatment of allergic symptoms. Azatadine has been shown to bind to voltage-dependent calcium channels and inhibit their opening, preventing the release of neurotransmitters such as acetylcholine. Azatadine also blocks leukotriene receptors and therefore its activity is antagonistic with fatty acid synthase inhibitors and other pharmacological agents.
Azatadine dimaleate (AZA) is a prodrug that is metabolized in vivo by esterases into the active form, azatadine. AZA inhibits histamine release from mast cells in vitro and in vivo models. This drug also has anti-inflammatory properties that may be due to its inhibition of prostaglandin synthesis.
Azatadine dimaleate (AZA) is a prodrug that is metabolized in vivo by esterases into the active form, azatadine. AZA inhibits histamine release from mast cells in vitro and in vivo models. This drug also has anti-inflammatory properties that may be due to its inhibition of prostaglandin synthesis.
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Chemische Eigenschaften
Molekulargewicht:522.55 g/mol
Formel:C20H22N2·2C4H4O4
Reinheit:Min. 95%
InChl:InChI=1S/C20H22N2.2C4H4O4/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19;2*5-3(6)1-2-4(7)8/h2-7,12H,8-11,13-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
InChI Key:InChIKey=SGHXFFAHXTZRQM-SPIKMXEPSA-N
SMILES:CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O