5-Amino-8-hydroxyquinoline dihydrochloride

CAS: 21302-43-2

Ref. 3D-FA40514

Produktinformation

• Name: 5-Amino-8-hydroxyquinoline dihydrochloride
• Synonyme: 5-Amino-8-Hydroquinoline Dihydrochloride, 5-Amino-8-Hydroxyquinoline Dihydrochloride, 5-Amino-8-Hydroxyquinoline Dihydrochloride 97+%, 5-Amino-8-Hydroxyquinoline2Hcl, 5-Amino-8-Quinolinol Dihydrochloride, 5-Aminoquinolin-8-Ol Dihydrochloride, 8-Quinolinol, 5-Amino-, Dihydrochloride, 8-Quinolinol, 5-amino-, hydrochloride (1:2)

Beschreibung

5-Amino-8-hydroxyquinoline dihydrochloride (5-AQDH) is an anticancer drug that inhibits the activity of survivin, a protein that is overexpressed in cancer cells. It has been shown to be effective in vivo against melanoma tumor growth. 5-AQDH binds to the unpaired cysteine residues of the survivin molecule and inhibits its function by binding to the active site, blocking access to ATP and preventing DNA synthesis. The efficacy of 5-AQDH has been confirmed in vitro by studying the effect on cell viability and DNA synthesis, as well as by measuring plasma mass spectrometry data from melanoma patients. This drug is currently being investigated for its potential use as an anticancer agent.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 212.63 g/mol
• Formel: C₉H₈N₂O•(HCl)₂
• Reinheit: Min. 95%