2-Amino-3-bromo-5-chloropyrazine

CAS: 76537-18-3

Ref. 3D-FA42372

Produktinformation

• Name: 2-Amino-3-bromo-5-chloropyrazine
• Synonyme: (3-Bromo-5-chloropyrazin-2-yl)amine, 2-Pyrazinamine, 3-Bromo-5-Chloro-, 3-Bromo-5-chloro-2-aminopyrazine, 3-Bromo-5-chloro-2-pyrazinamine, 3-Bromo-5-chloropyrazin-2-amine, Pyrazinamine, 3-bromo-5-chloro-

Beschreibung

2-Amino-3-bromo-5-chloropyrazine (2ABPC) is a hydrophobic, nucleophilic, and reactive nitrile that can be used to synthesize pharmaceutically active compounds. It is synthesized by the reaction of 2-aminopyridine with bromochloromethane in the presence of sodium methoxide. The synthesis of 2ABPC is highlighted in the scheme below:

The first step in this process involves the chlorination of 2-aminopyridine to produce 2-(chloromethyl)pyridine. The second step is a regioselective nitration using bromochloromethane in the presence of sodium methoxide to produce 2-(chloromethyl)-5-nitropyridine. Finally, reduction with hydrogen gas and hydrochloric acid produces 2ABPC.

• Marke: Biosynth

Chemische Eigenschaften

• Reinheit: Min. 95%