3-Acetylbenzenesulfonyl chloride

CAS: 73035-16-2

Ref. 3D-FA58966

Produktinformation

• Name: 3-Acetylbenzenesulfonyl chloride
• Synonyme: 3-Acetyl-benzenesulfonyl chloride, Benzenesulfonyl chloride, 3-acetyl-

Beschreibung

3-Acetylbenzenesulfonyl chloride is a potent inhibitor of the CFTR protein that is used to treat cystic fibrosis. It blocks chloride transport and reduces the number of mutations in the CFTR gene. 3-Acetylbenzenesulfonyl chloride has been shown to be synergistic with other drugs, such as VX-809, which inhibits another enzyme, ABCG2. This drug also has a chemical group that can bind to DNA and RNA to inhibit transcription and translation. 3-Acetylbenzenesulfonyl chloride binds to the F508del-CFTR protein by covalent modification, reducing incorrectors that are produced when the gene is mutated.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 218.66 g/mol
• Formel: C₈H₇SO₃Cl
• Reinheit: Min. 95%
• InChl: InChI=1S/C8H7ClO3S/c1-6(10)7-3-2-4-8(5-7)13(9,11)12/h2-5H,1H3
• InChI Key: InChIKey=CGMBNEIGZOCPPP-UHFFFAOYSA-N
• SMILES: CC(=O)c1cccc(S(=O)(=O)Cl)c1