2-Aminochrysene

CAS: 789-47-9

Ref. 3D-FA66865

Produktinformation

• Name: 2-Aminochrysene
• Marke: Biosynth
• Beschreibung: 2-Aminochrysene is a chemical that binds to DNA and causes a genotoxic effect. It has been shown to be carcinogenic to rats and is carcinogenic in humans. 2-Aminochrysene is metabolized by conjugation with glucuronic acid or glutathione, which are found in the liver, kidney, and other tissues. The binding constants for 2-aminochrysene were measured using the calf thymus DNA as a substrate and amines as ligands. Transfer of 2-aminochrysene from the plasma membrane to the cytosol was observed in cells treated with nitrous oxide (NO). The cytosolic enzyme binding assay showed that 2-aminochrysene binds to the S9 protein of hepatic microsomes.2-Aminochrysene has also been shown to inhibit phospholipase A2 activity, which may be due to its ability to bind to the enzyme's active site.

Chemische Eigenschaften

• Molekulargewicht: 243.3 g/mol
• Formel: C₁₈H₁₃N
• Reinheit: Min. 95%
• Farbe/Form: Yellow Powder
• InChl: InChI=1S/C18H13N/c19-14-7-10-16-13(11-14)6-9-17-15-4-2-1-3-12(15)5-8-18(16)17/h1-11H,19H2
• InChI Key: InChIKey=KSDIHKMNSYWRFB-UHFFFAOYSA-N
• SMILES: Nc1ccc2c(ccc3c4ccccc4ccc23)c1