4,7-Dichloro-1,10-phenanthroline

CAS: 5394-23-0

Ref. 3D-FAA39423

Produktinformation

• Name: 4,7-Dichloro-1,10-phenanthroline
• Synonyme: 1,10-Phenanthroline, 4,7-dichloro-, 4,7-Dichloro-o-phenanthroline, K0052, NSC 626

Beschreibung

4,7-Dichloro-1,10-phenanthroline is a bidentate ligand that binds to the chloride anion and has been shown to have anticancer activity against leukemia cells. This compound has also been shown to inhibit the proliferation of cervical cancer cells and chronic myeloid leukemia cells. 4,7-Dichloro-1,10-phenanthroline enhances the fluorescence of human chronic myeloid leukemia cells in a cytometry assay by increasing hydrogen bonding between the cell membrane and fluorophore. This enhancement effect was seen at concentrations of 0.01 μM and higher. 4,7-Dichloro-1,10-phenanthroline also binds to DNA and has been shown to be effective against cancer cells in a luminescent human chronic myeloid leukemia (MRC5) assay.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 249.09 g/mol
• Formel: C₁₂H₆Cl₂N₂
• Reinheit: Min. 95%