N-t-Boc-valacyclovir

CAS: 502421-44-5

Ref. 3D-FB18986

Produktinformation

• Name: N-t-Boc-valacyclovir
• Synonyme: N-tert-Butoxycarbonyl-L-valine-2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester
• Marke: Biosynth
• Beschreibung: Valacyclovir is a prodrug that is hydrolyzed to acyclovir in the body. Valacyclovir is an ester of valine and cyclovir. The synthesis starts with the coupling of N-t-Boc-valine to 2,4-dichlorobenzyl alcohol. The product is then subjected to hydrolysis with hydrochloric acid in refluxing isopropanol, which yields N-t-Boc-valacyclovir. Hydrolysis of this compound under basic conditions gives the desired acyclovir. Acetylation of the hydroxyl group on the side chain of valine forms a methyl ester, which can be cleaved using an acidic solution (e.g., HCl) to give valacyclovir.

Chemische Eigenschaften

• Molekulargewicht: 424.45 g/mol
• Formel: C₁₈H₂₈N₆O₆
• Reinheit: Min. 95%
• Farbe/Form: Powder