(S)-4-tert-Butyl-2-(2-pyridyl)oxazoline
CAS: 117408-98-7
Ref. 3D-FB60868
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Produktinformation
Name:
(S)-4-tert-Butyl-2-(2-pyridyl)oxazoline
Synonyme:
- (S)-4-(tert-Butyl)-2-(2-pyridyl)-4,5-dihydrooxazole
- (4S)-4-tert-butyl-2-pyridin-2-yl-4,5-dihydro-1,3-oxazole
- 2-[(4S)-4-tert-Butyl-4,5-dihydro-2-oxazolyl]pyridine
Beschreibung:
(S)-4-tert-Butyl-2-(2-pyridyl)oxazoline is an enantiopure compound that has been obtained by a catalytic asymmetric method. This new synthetic method is based on the preparation of aziridines from aryl chlorides and alkynes and the subsequent reactions with picolinic acid. The aziridines are prepared in good yields in short reaction times and with high stereoselectivity. The synthesis of (S)-4-tert-butyl-2-(2-pyridyl)oxazoline can be scaled up for preparative purposes. Optimization studies have led to a scalable synthesis of this compound, which can be applied to other challenging targets.
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Marke:
Biosynth
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Chemische Eigenschaften
Molekulargewicht:
204.27 g/mol
Formel:
C12H16N2O
Reinheit:
Min. 95%
InChl:
InChI=1S/C12H16N2O/c1-12(2,3)10-8-15-11(14-10)9-6-4-5-7-13-9/h4-7,10H,8H2,1-3H3
InChI Key:
InChIKey=JDOAIDZRVWJBEG-UHFFFAOYSA-N
SMILES:
CC(C)(C)C1COC(c2ccccn2)=N1
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