6-Chloro-7-deazaguanine

CAS: 84955-31-7

Ref. 3D-FC06299

Produktinformation

• Name: 6-Chloro-7-deazaguanine
• Synonyme: 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine, 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine, 2-Amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Beschreibung

6-Chloro-7-deazaguanine (6CDG) is a pyrimidine nucleoside that is used in the treatment of hepatoblastoma and hepatitis. 6CDG is an alkylating agent that binds to DNA and causes strand breakage by forming covalent bonds with the N-7 position of guanine. It can also be used as an antiviral agent against herpes simplex virus, as it inhibits viral replication by inhibiting the viral DNA polymerase. 6CDG does not inhibit human DNA polymerase. The drug has been shown to be cytotoxic to MRC5 cells, which are resistant to pyrimidine analogs.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 168.58 g/mol
• Formel: C₆H₅ClN₄
• Reinheit: Min. 95%
• Farbe/Form: Powder
• InChl: InChI=1S/C6H5ClN4/c7-4-3-1-2-9-5(3)11-6(8)10-4/h1-2H,(H3,8,9,10,11)
• InChI Key: InChIKey=VIVLSUIQHWGALQ-UHFFFAOYSA-N
• SMILES: Nc1nc(Cl)c2cc[nH]c2n1