CCT 241533 hydrochloride

CAS: 1431697-96-9

Ref. 3D-FC104262

Produktinformation

• Name: CCT 241533 hydrochloride
• Synonyme: 3-Pyrrolidinemethanol, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-, hydrochloride (1:1), (3R,4S)-rel-

Beschreibung

Potent and specific inhibitor of checkpoint kinase CHK2 with IC50 of 3 nM. CCT 241533 binds to the ATP pocket of CHK2 and shows minimal cross-reactivity against related kinases. CCT 241533 blocked the activity of CHK2 and impaired DNA repair in response to DNA damage in human tumoral cell lines. The compound did not potentiate genotoxicity of several genotoxic compounds but it did potentiate the cytotoxicity of a PARP inhibitor olaparib.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 478.94 g/mol
• Formel: C₂₃H₂₇FN₄O₄•HCl
• Reinheit: Min. 95%