10-(Chloroacetyl)-10H-phenothiazine

CAS: 786-50-5

Ref. 3D-FC127612

Produktinformation

• Name: 10-(Chloroacetyl)-10H-phenothiazine
• Synonyme: 10H-phenothiazine, 10-(chloroacetyl)-, 10-(Chloroacetyl)phenothiazine, 10H-Phenothiazine, 10-(chloroacetyl)-, 2-Chloro-1-(10H-phenothiazin-10-yl)ethan-1-one, 2-Chloro-1-phenothiazin-10-yl-ethanone, 2-Chloro-1-phenothiazin-10-ylethanone, 2-chloro-1-(10H-phenothiazin-10-yl)ethanone, Ethanone, 2-chloro-1-(10H-phenothiazin-10-yl)-, N-(Chloroacetyl)phenothiazine, NSC 239984, NSC 71676, Phenothiazine, 10-(chloroacetyl)-

Beschreibung

10-(Chloroacetyl)-10H-phenothiazine is an anti-cancer drug that has significant activity against cervical cancer cells. It also has antimicrobial properties and can be used as a broad-spectrum antibiotic and antifungal agent. 10-(Chloroacetyl)-10H-phenothiazine is active against both Gram-positive and Gram-negative bacteria, including Mycobacterium tuberculosis and Candida albicans. 10-(Chloroacetyl)-10H-phenothiazine binds to DNA by intercalating in the DNA double helix, with the chloroacetyl group forming a covalent bond with the DNA base guanine. This binding alters the conformation of the DNA, causing negative supercoiling of the molecule.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 275.75 g/mol
• Formel: C₁₄H₁₀ClNOS
• Reinheit: Min. 95%
• InChl: InChI=1S/C14H10ClNOS/c15-9-14(17)16-10-5-1-3-7-12(10)18-13-8-4-2-6-11(13)16/h1-8H,9H2
• InChI Key: InChIKey=NVRFGQJNKQLUPU-UHFFFAOYSA-N
• SMILES: O=C(CCl)N1c2ccccc2Sc2ccccc21