6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one

CAS: 1242156-53-1

Ref. 3D-FC161324

Produktinformation

• Name: 6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one

Beschreibung

6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one is a potent and selective inhibitor of tyrosine kinases. The compound was discovered by screening for inhibitors of the PDGF receptor in a cellular assay. The structure activity relationship analysis revealed that the 6-cyclopropyl group and 8-fluoroisoquinoline moiety are critical for the inhibitory potency and selectivity. In particular, the 8-fluoroisoquinoline moiety is important for binding to the ATP site on PDGFRs, as well as for binding to other tyrosine kinases such as c-Met, c-Kit, cRaf, cSrc, and EGFR. 6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one has been shown to have potential therapeutic applications in rheumatoid arthritis by inhibiting the production of proinflammatory cytokines in

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 203.21 g/mol
• Formel: C₁₂H₁₀FNO
• Reinheit: Min. 95%
• InChl: InChI=1S/C12H10FNO/c13-10-6-9(7-1-2-7)5-8-3-4-14-12(15)11(8)10/h3-7H,1-2H2,(H,14,15)
• InChI Key: InChIKey=LDOIRSRUYDIUTP-UHFFFAOYSA-N
• SMILES: O=c1[nH]ccc2cc(C3CC3)cc(F)c12