6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one
CAS: 1242156-53-1
Ref. 3D-FC161324
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Produktinformation
Name:
6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one
Beschreibung:
6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one is a potent and selective inhibitor of tyrosine kinases. The compound was discovered by screening for inhibitors of the PDGF receptor in a cellular assay. The structure activity relationship analysis revealed that the 6-cyclopropyl group and 8-fluoroisoquinoline moiety are critical for the inhibitory potency and selectivity. In particular, the 8-fluoroisoquinoline moiety is important for binding to the ATP site on PDGFRs, as well as for binding to other tyrosine kinases such as c-Met, c-Kit, cRaf, cSrc, and EGFR. 6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one has been shown to have potential therapeutic applications in rheumatoid arthritis by inhibiting the production of proinflammatory cytokines in
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Marke:
Biosynth
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Chemische Eigenschaften
Molekulargewicht:
203.21 g/mol
Formel:
C12H10FNO
Reinheit:
Min. 95%
InChl:
InChI=1S/C12H10FNO/c13-10-6-9(7-1-2-7)5-8-3-4-14-12(15)11(8)10/h3-7H,1-2H2,(H,14,15)
InChI Key:
InChIKey=LDOIRSRUYDIUTP-UHFFFAOYSA-N
SMILES:
O=c1[nH]ccc2cc(C3CC3)cc(F)c12
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