Coptisine chloride

CAS: 6020-18-4

Ref. 3D-FC20553

Produktinformation

• Name: Coptisine chloride
• Synonyme: 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium chloride, 6,7-Dihydro[1,3]Dioxolo[4,5-G][1,3]Dioxolo[7,8]Isoquino[3,2-A]Isoquinolin-5-Ium, 6,7-Dihydro[1,3]Dioxolo[4,5-G][1,3]Dioxolo[7,8]Isoquino[3,2-A]Isoquinolin-5-Ium Chloride, 7,12b-dihydro-6H-[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquino[3,2-a]isoquinoline, 7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium chloride, Berbinium, 7,8,13,13a-tetradehydro-2,3:9,10-bis(methylenedioxy)-, chloride, Bis[1,3]benzodioxolo[5,6-a:4′,5′-g]quinolizinium, 6,7-dihydro-, chloride, Bis[1,3]benzodioxolo[5,6-a:4′,5′-g]quinolizinium, 6,7-dihydro-, chloride (1:1), Coptisine hydrochloride

Beschreibung

Coptisine chloride is a natural compound that has been shown to have significant cytotoxicity against cancer cells. Coptisine chloride inhibits the mitochondrial membrane potential and induces apoptosis in myeloma cells. It also inhibits the production of proinflammatory cytokines, such as tumor necrosis factor-α, IL-1β, and IL-6, in activated macrophages. Coptisine chloride also has an inhibitory effect on toll-like receptor 4 (TLR4), which is important for the development of inflammatory responses. The structure of coptisine chloride was determined by molecular docking analysis and it was found to bind to ATP synthase. In addition, coptisite chloride inhibited polymerase chain reaction (PCR) amplification of DNA templates in vitro. This compound can be used as a lead compound for the development of novel anti-inflammatory drugs.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 355.77 g/mol
• Formel: C₁₉H₁₄ClNO₄
• Reinheit: Min. 95%