Cyclopamine

CAS: 4449-51-8

Ref. 3D-FC20718

Produktinformation

• Name: Cyclopamine
• Synonyme: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetrameth ylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol, (2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-1,2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11,11a,11b-Octadecahydro-3′,6′,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-3-ol, (3beta,22S,23R)-17,23-epoxyveratraman-3-ol, 11-Deoxojervine, 11-Deoxyjervine, Hsdb 3505, Jervine, 11-deoxo-, Jervine, 11-deoxo- (7CI), Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)pyridin)-3-ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-, Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11,11a,11b-octadecahydro-3′,6′,10,11b-tetramethyl-, (2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-, Veratraman-3-ol, 17,23-epoxy-, (3-beta,23-beta)- (9CI), Veratraman-3-ol, 17,23-epoxy-, (3beta,23beta)-, Veratraman-3-ol, 17,23-epoxy-, (3β,23β)-

Beschreibung

Inhibitor of the Smoothened receptor and Hedgehog signalling pathway. Cyclopamine is a steroidal alkaloid that binds to the heptahelical bundle of Smoothened and negatively regulates transcription of downstream genes. In prostate cancer cells, cyclopamine inhibited cell growth, arrested cell cycle and in glioblastoma, it depleted stem cell-like cancer cells.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 411.31373
• Formel: C₂₇H₄₁NO₂
• Reinheit: Min. 95%
• Farbe/Form: White Solid