Efavirenz

CAS: 154598-52-4

Ref. 3D-FC30275

Produktinformation

• Name: Efavirenz
• Synonyme: (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
• Marke: Biosynth
• Beschreibung: Efavirenz is a non-nucleoside-based reverse transcriptase inhibitor (NNRTI) of the reverse transcriptase of HIV-1. It inhibits the viral enzyme reverse transcriptase by binding to its active site. In certain cell culture assays, efavirenz showed great efficiency when inhibiting wild-type HIV-1 replication with values of inhibition constant Ki between 2.97 to 17.60 mM in single mutation enzymes and 26.05 to 56.50 nM in double mutation. In the treatment of HIV, efavirenz has been studied in combination with emtricitabine and tenofovir disoproxil fumarate for ease of administration in some clinical studies. Recent in vitro cell studies indicated efavirenz is a potential treatment for pancreatic, prostate and triple-negative breast cancers due to its cytotoxicity against cancer cells, with an EC50 of 31.5 μM.

Chemische Eigenschaften

• Molekulargewicht: 315.68 g/mol
• Formel: C₁₄H₉ClF₃NO₂
• Reinheit: Min. 95%
• Farbe/Form: Powder
• SMILES: O=C1Nc2ccc(Cl)cc2C(C#CC2CC2)(C(F)(F)F)O1